The inhibitory effect of glucocorticoids on corticotroph POMC expression appears, in the rat POMC promoter, to be dependent on a glucocorticoid response element partially overlapping the CCAAT box (27)
2.4 Monitoring microbial growth Microbial growth was monitored by direct microscopic counts using a Leica DM2000 LED microscope equipped with a Leica DFC7000 T CCD camera, following staining with SYBR TM Green nucleic acid stain at 1,000 magnification (Invitrogen TM ), following the modified protocol of Summers et al
10.1002/ptr.7305 2 AbotalebM.LiskovaA.KubatkaP.BsselbergD
Importantly, combination of metformin and radiation significantly increased cell death, when compared to irradiated vehicle controls, highlighting the potential role for altered cell death in the metformin-mediated radiosensitisation of these cell lines
Suivi Rgulier : Un suivi rgulier avec un mdecin est recommand pour valuer lefficacit du traitement